5-Amino-1MQ Safety Information

5-Amino-1MQ is a small, selective, membrane-permeable molecule that works by inhibiting an enzyme called nicotinamide N-methyltransferase (NNMT). NNMT is involved in regulating metabolism, cellular energy, and fat storage.

Increased NNMT activity is associated with slowed metabolism, fat accumulation, and metabolic decline with aging. By reducing NNMT activity, 5-Amino-1MQ may help restore the body's natural fat-burning ability and support healthy weight loss, especially in adults experiencing age-related metabolic slowdown.

How It Works

-NNMT levels are often elevated in white adipose (fat) tissue

-5-Amino-1MQ helps lower NNMT activity, which may:

-Improve metabolic function

-Support fat loss

-Boost intracellular levels of NAD⁺ and SAM, critical molecules involved in cellular energy and repair

-This medication does not interfere with other metabolic enzymes, making it a targeted option with a lower potential for widespread side effects.

Potential Benefits

May reduce age-related fat storage

Can support weight loss when combined with a healthy lifestyle

May help improve energy metabolism

Potential for preventing or reversing insulin resistance and type 2 diabetes

Important Safety Notes

5-Amino-1MQ is a research-based therapy and may be prescribed off-label as part of a medical weight loss plan. While early results from animal studies are promising, ongoing research is being conducted to better understand its long-term effects and optimal dosing in humans.

Supporting Clinical Study

Neelakantan H, Vance V, Wetzel MD, Wang HL, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ.

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice.

Biochem Pharmacol. 2018 Jan;147:141–152.

DOI: 10.1016/j.bcp.2017.11.007

GHK-Copper Safety Information

GHK-Copper (glycyl-L-histidyl-L-lysine:Cu) is a naturally occurring copper-binding peptide found in human plasma. It plays a key role in skin regeneration, tissue repair, and anti-aging processes. Levels of GHK naturally decline with age, which may contribute to visible signs of aging and delayed healing.

GHK-Copper has been extensively studied for its ability to stimulate collagen production, tighten and rejuvenate the skin, and support healthy hair growth. It is also believed to help modulate genes associated with inflammation, oxidative stress, and tissue remodeling.

Potential Benefits

Improves skin elasticity, firmness, and tone

Reduces the appearance of fine lines and wrinkles

Promotes hair follicle health and hair regrowth

Aids in wound healing and tissue repair

Provides anti-inflammatory and antioxidant support

May help protect against UV radiation and environmental stressors

Shown to support healing in skin, gut, bone, lung, and liver tissue

Mechanism of Action

GHK-Copper works by:

Stimulating collagen and glycosaminoglycan synthesis

Regulating gene expression related to tissue regeneration

Binding copper, an essential trace mineral that supports enzymatic functions and healing

It is also reported to calm inflammation, support antioxidant defenses, and modulate pain and anxiety pathways, making it a well-rounded option in regenerative medicine.

Clinical Research

Pickart L., et al. The effect of human peptide GHK on gene expression relevant to nervous system function and cognitive decline. Brain Sci. 2017; 7(2):20.

Pickart L., et al. GHK-copper peptide in skin remodeling and anti-aging. SDFW J. 2010; 136(6):1-9.

Huang PJ, et al. Influence of copper peptide aids on LED-irradiated fibroblast collagen synthesis. Photomed. Laser Surg. 2007; 25:183–190.

LGD-4033 Safety Information

Also known as Ligandrol, is a Selective Androgen Receptor Modulator (SARM) that has demonstrated potent anabolic activity in muscle and bone. Originally studied for conditions like muscle wasting and osteoporosis, LGD-4033 may also be prescribed off-label in adults to support increased lean muscle mass, strength, fat loss, and exercise recovery.

How It Works

LGD-4033 selectively binds to androgen receptors in muscle and bone tissues, stimulating anabolic activity without the same androgenic effects seen with traditional anabolic steroids. This allows for potential muscle-building benefits with fewer side effects.

Potential Benefits

Increased lean muscle mass

Enhanced strength and physical performance

Improved exercise recovery

Support in reducing body fat

Preservation of bone density

Pharmacokinetic Profile

Favorable safety profile in clinical trials

Long half-life, allowing for convenient dosing

Minimal changes in liver enzymes (AST/ALT), hemoglobin, PSA, or heart rhythm (QT interval) in research studies

Does not significantly increase prostate-specific antigen (PSA) levels

Hormonal Considerations

At higher doses (1.0 mg), LGD-4033 has been associated with:

Suppression of total testosterone and free testosterone

Decrease in sex hormone-binding globulin (SHBG)

Reduced follicle-stimulating hormone (FSH)

Decreased HDL cholesterol and triglycerides

Monitoring by a licensed healthcare provider is important to ensure safe and effective use.

Clinical Research

Solomon ZJ, et al. Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications. Sex Med Rev. 2019;7(1):84-94.

Basaria S, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral SARM, in healthy young men. J Gerontol A Biol Sci Med Sci. 2013;68(1):87-95.

LGD-4033 is not FDA-approved and is available only through compounded prescriptions when a licensed provider determines it to be medically appropriate. It is intended for adult use only and should always be used under the supervision of a qualified medical provider.

This information is for educational purposes only and does not replace medical advice. All care decisions at Boggs Wellness are made in collaboration with your provider, based on your unique health profile and goals.